Microalbumin ELISA
Specification:
Catalog Number: Microalbumin HU-LB12
Description: Microalbumin  ELISA
Sample Type: Whole Blood
Sample Size: 200 µl
Available Sizes: 96 Wells
Incubation: 1 hour(s) 30 minutes (s)
Protocol: Microalbumin  ELISA
Regulatory Status: RUO
Product Distribution: Available worldwide
Under normal physiological conditions very little albumin is present in the urine. Approximately 99% of the filtered albumin is reabsorbed in the proximal tubule. In pathologic conditions when glomerular capillary wall permeability and/or filtration rate increase, albumin excretion along with other macromolecules in urine also increases. On the other hand, when proximal tubular reabsorptive capacity decreases, excretion of smaller macromolecules such as beta 2 micro globulin and lysozyme in urine increases. Thus, determining the clearance ratio of urinary albumin to beta 2 micro globulin can help localize the site of renal impairment.
Detection of increased urinary albumin excretion is of particular importance in the early diagnosis of incipient renal disease. Thus, a sensitive method of measuring minor increase in urinary albumin is of great significance to a) detect minimal renal impairment and b) to control its progression in developing end stage renal disease and cardiovascular disease amongst diabetics. A recent consensus report by Centers for Disease Control and the National Institute of Diabetes and Digestive and Kidney diseases recommend that albumin in the urine amongst diabetics be routinely monitored. Although the microalbuminuria is tested primarily in diabetes mellitus, it has also been used in studies of hypertension, pregnancy (pre-eclamsio, maternal morbidity and fetal mortality) non-diabetic renal disease and the renal effects of various drugs, hormones, and nephrotoxins.
Microalbumin ELISA - For the quantitative determination of albumin in human urine.